Glargine

EnglishSpanishDrug Class & Related Drugs
Insulin glargine is analogous with long-acting human insulin. It is obtained through recombinant DNA technology by using a non pathogenic lab strain of Escherichia coli (K12) as the producing organism, which has two molecules of arginine substituted. This results into an insulin that is soluble in an acidic pH 4.0 – 5.0 medium, which crystallizes after the injection due to the presence of physiological pH (7.4) in the subcutaneous tissue, this being the reason for the long duration of its action. To stabilize the conditions of solubility in an acidic medium and the precipitation, which leads to tissue degradation, a second change was made by substituting the aspargine at position 21 on the α chain (from regular insulin) for a glycine.
La insulina glargina es un análogo de la insulina humana recombinada de larga duración (24hs). Se obtiene por tecnología recombinante de ADN, utilizando una cepa de laboratorio no patógena de Escherichia coli (K12) como organismo productor, a la cual se le sustituyen dos moléculas de arginina. El resultado es una insulina soluble en un medio ácido con pH de 4.0 – 5.0, que luego de la inyección cristaliza a pH fisiológico (7.4) en el tejido subcutáneo, de aquí su acción prolongada en el tiempo. Para estabilizar las condiciones de solubilidad en medio ácido y la precipitación, que producían la degradación del tejido, se hizo una segunda modificación sustituyendo la aspargina de la posición 21 de la cadena α (de la insulina regular) por una glicina.
Drugs associated with Diabetes, Type 2

Insuline Glargine

Actos generic name: pioglitazone class: thiazolidinediones
Amaryl generic name: glimepiride class: sulfonylureas
Bydureon generic name: exenatide class: incretin mimetics
Byetta generic name: exenatide class: incretin mimetics
Farxiga generic name: dapagliflozin class: SGLT-2 inhibitors
Glucophage generic name: metformin class: non-sulfonylureas
Glucotrol generic name: glipizide class: sulfonylureas
Humalog generic name: insulin lispro class: insulin
Invokana generic name: canagliflozin class: SGLT-2 inhibitors
Janumet generic name: metformin/sitagliptin class: antidiabetic combinations
Januvia generic name: sitagliptin class: dipeptidyl peptidase 4 inhibitors
Kombiglyze XR generic name: metformin/saxagliptin class: antidiabetic combinations
Lantus generic name: insulin glargine class: insulin
Lantus Solostar generic name: insulin glargine class: insulin
Levemir generic name: insulin detemir class: insulin
Novolog generic name: insulin aspart class: insulin
Onglyza generic name: saxagliptin class: dipeptidyl peptidase 4 inhibitors
Tradjenta generic name: linagliptin class: dipeptidyl peptidase 4 inhibitors
Victoza generic name: liraglutide class: incretin mimetics
Welchol generic name: colesevelam class: bile acid sequestrants
Drugs associated with Diabetes, Type 1
Apidra generic name: insulin glulisine class: insulin
Exubera (Pro, More…)
generic name: insulin inhalation, rapid acting class: insulin
Humalog generic name: insulin lispro class: insulin
Humalog KwikPen generic name: insulin lispro class: insulin
Humalog Mix 75 / 25 generic name: insulin lispro/insulin lispro protamine class: insulin
Humulin 70 / 30 generic name: insulin isophane/insulin regular class: insulin
Humulin N generic name: insulin isophane class: insulin
Humulin R generic name: insulin regular class: insulin
Lantus generic name: insulin glargine class: insulin
Lantus Solostar generic name: insulin glargine class: insulin
Levemir generic name: insulin detemir class: insulin
Novolin 70 / 30 generic name: insulin isophane/insulin regular class: insulin
Novolin N generic name: insulin isophane class: insulin
Novolin R generic name: insulin regular class: insulin
Novolog generic name: insulin aspart class: insulin
NovoLog FlexPen generic name: insulin aspart class: insulin
NovoLog Mix 70 / 30 generic name: insulin aspart/insulin aspart protamine class: insulin
NovoLog Mix 70 / 30 FlexPen generic name: insulin aspart/insulin aspart protamine class: insulin
Symlin generic name: pramlintide class: amylin analogs
Victoza generic name: liraglutide class: incretin mimetics